And what we see in the spinal cord is that most of the gray Looking down this way at the different sections These sections from the top, so that we're kind of Like if we were cutting a loaf of bread and kind of cut from the What these drawings represent are different levels of the spinal cord. Really nice illustration of some different sections If we look first at the spinal cord here, and here we have a Gray matter and white matter is a little different between And so these are the names that have stuck for these general areas, the gray matter and the white matter.

Prepared certain ways after being removed from the body, it can have a grayish appearance or a more whitish appearance.

Kinda funny names for these parts of the central nervous system because they're really not gray or white. Myelinated, so axons thatĪre wrapped in myelin. The central nervous system, is most of the 'myelinated axons'. And then there are otherĪreas called 'white matter'. In the central nervous system are found in the gray matter. In the central nervous system, which is mostly the brainĪnd the spinal cord, there are areas called 'gray matter' gray matter, that contain most of the 'neuron somas'. As spinal cord injuries are often located at spinal enlargements, this research lays the groundwork for new neuroregenerative therapies to replace these lost neuronal pools vital to sensorimotor function.Voiceover: In this video, I'm gonna talk about Animals do not regain lost sensorimotor function three months after injury, indicating that natural recovery of the spinal cord cannot compensate for loss of laminae V-VII neurons. White matter damage and lower motoneuron loss did not correlate with behavioral deficits. Machine-learning quantification confirmed interneuronal damage to laminae V-VII in spinal L2-L4 correlates with hindlimb dysfunction. Using a Random Forest algorithm, we combined these behavioral assessments into a highly predictive binary classification system which strongly correlated with structural deficits in the rostro-caudal axis. A thorough, tailored behavioral evaluation revealed deficits in gross hindlimb function, skilled walking, coordination, balance and gait two-weeks post-injury. We modified a kainic acid lesion to damage intermediate gray matter (laminae V-VII) in the lumbar spinal enlargement (spinal L2-L4) in female rats.

While genetic knockouts examine the function of unique spinal interneuron (SpIN) subtypes, the phenotype of combined premotor interneuron loss remains to be explored. Locomotion is a complex task involving excitatory and inhibitory circuitry in spinal gray matter.

Gray matter of spinal cord